Phenotypic clustering of dilated cardiomyopathy patients highlights important pathophysiological differences.

ABSTRACT:

Aims

The dilated cardiomyopathy (DCM) phenotype is the result of combined genetic and acquired triggers. Until now, clinical decision-making in DCM has mainly been based on ejection fraction (EF) and NYHA classification, not considering the DCM heterogenicity. The present study aimed to identify patient subgroups by phenotypic clustering integrating aetiologies, comorbidities, and cardiac function along cardiac transcript levels, to unveil pathophysiological differences between DCM subgroups.

Methods and results

We included 795 consecutive DCM patients from the Maastricht Cardiomyopathy Registry who underwent in-depth phenotyping, comprising extensive clinical data on aetiology and comorbodities, imaging and endomyocardial biopsies. Four mutually exclusive and clinically dis

SUBMITTER: Verdonschot JAJ 

PROVIDER: S-EPMC7813623 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature