Multiparametric functional MRI and ¹⁸F-FDG-PET for survival prediction in patients with head and neck squamous cell carcinoma treated with (chemo)radiation.

ABSTRACT:

Objectives

To assess (I) correlations between diffusion-weighted (DWI), intravoxel incoherent motion (IVIM), dynamic contrast-enhanced (DCE) MRI, and ¹⁸F-FDG-PET/CT imaging parameters capturing tumor characteristics and (II) their predictive value of locoregional recurrence-free survival (LRFS) and overall survival (OS) in patients with head and neck squamous cell carcinoma (HNSCC) treated with (chemo)radiotherapy.

Methods

Between 2014 and 2018, patients with histopathologically proven HNSCC, planned for curative (chemo) radiotherapy, were prospectively included. Pretreatment clinical, anatomical, and functional imaging parameters (obtained by DWI/IVIM, DCE-MRI, and ¹⁸F-FDG-PET/CT) were extracted for primary tumors (PT) and lymph node metastases. Correl

SUBMITTER: Martens RM 

PROVIDER: S-EPMC7813703 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature