Excitatory-inhibitory balance within EEG microstates and resting-state fMRI networks: assessed via simultaneous trimodal PET-MR-EEG imaging.

ABSTRACT: The symbiosis of neuronal activities and glucose energy metabolism is reflected in the generation of functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) signals. However, their association with the balance between neuronal excitation and inhibition (E/I-B), which is closely related to the activities of glutamate and γ-aminobutyric acid (GABA) and the receptor availability (RA) of GABA_A and mGluR5, remains unexplored. This research investigates these associations during the resting state (RS) condition using simultaneously recorded PET/MR/EEG (trimodal) data. The trimodal data were acquired from three studies using different radio-tracers such as, [¹¹C]ABP688 (ABP) (N = 9), [¹¹C]Flumazenil (FMZ) (N = 10) and 2-[¹⁸F]fluoro

SUBMITTER: Rajkumar R 

PROVIDER: S-EPMC7813876 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature