Identification of a neutralizing epitope within minor repeat region of Plasmodium falciparum CS protein.

ABSTRACT: Malaria remains a major cause of morbidity and mortality worldwide with 219 million infections and 435,000 deaths predominantly in Africa. The infective Plasmodium sporozoite is the target of a potent humoral immune response that can protect murine, simian and human hosts against challenge by malaria-infected mosquitoes. Early murine studies demonstrated that sporozoites or subunit vaccines based on the sporozoite major surface antigen, the circumsporozoite (CS) protein, elicit antibodies that primarily target the central repeat region of the CS protein. In the current murine studies, using monoclonal antibodies and polyclonal sera obtained following immunization with P. falciparum sporozoites or synthetic repeat peptides, we demonstrate differences in the ability of these antibodies to re

SUBMITTER: Calvo-Calle JM 

PROVIDER: S-EPMC7813878 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature