Impact of tumor-parenchyma biomechanics on liver metastatic progression: a multi-model approach.

ABSTRACT: Colorectal cancer and other cancers often metastasize to the liver in later stages of the disease, contributing significantly to patient death. While the biomechanical properties of the liver parenchyma (normal liver tissue) are known to affect tumor cell behavior in primary and metastatic tumors, the role of these properties in driving or inhibiting metastatic inception remains poorly understood, as are the longer-term multicellular dynamics. This study adopts a multi-model approach to study the dynamics of tumor-parenchyma biomechanical interactions during metastatic seeding and growth. We employ a detailed poroviscoelastic model of a liver lobule to study how micrometastases disrupt flow and pressure on short time scales. Results from short-time simulations in detailed single hepatic lo

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7813881 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature