High-precision, gelatin-based, hybrid, bilayer scaffolds using melt electro-writing to repair cartilage injury.

ABSTRACT: Articular cartilage injury is a common disease in the field of orthopedics. Because cartilage has poor self-repairing ability, medical intervention is needed. Using melt electro-writing (MEW) technology, tissue engineering scaffolds with high porosity and high precision can be prepared. However, ordinary materials, especially natural polymer materials, are difficult to print. In this study, gelatin was mixed with poly (lactic-co-glycolic acid) to prepare high-concentration and high-viscosity printer ink, which had good printability and formability. A composite scaffold with full-layer TGF-β1 loading mixed with hydroxyapatite was prepared, and the scaffold was implanted at the cartilage injury site; microfracture surgery was conducted to induce the mesenchyme in the bone marrow. Quality ste

SUBMITTER: Han Y 

PROVIDER: S-EPMC7814104 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature