Multi-faceted enhancement of full-thickness skin wound healing by treatment with autologous micro skin tissue columns.

ABSTRACT: Impaired wound healing is an immense medical challenge, and while autologous skin grafting remains the "gold-standard" therapeutic option for repairing wounds that cannot be closed by primary or secondary intention, it is limited by substantial donor site morbidity. We previously developed the alternative approach of harvesting full-thickness skin tissue in the form of "micro skin tissue columns" (MSTCs), without causing scarring or any other long-term morbidity. In this study we investigated how MSTC treatment affects the different cellular processes involved in wound healing. We found that MSTC-derived cells were able to remodel and repopulate the wound volume, and positively impact multiple aspects of the wound healing process, including accelerating re-epithelialization by providing mu

SUBMITTER: Fuchs C 

PROVIDER: S-EPMC7814113 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature