Identification of Clock Genes Related to Hypertension in Kidney From Spontaneously Hypertensive Rats.

ABSTRACT:

Background

There is a diurnal variation in the blood pressure fluctuation of hypertension, and blood pressure fluctuation abnormality is considered to be an independent risk factor for organ damage including cardiovascular complications. In the current study, we tried to identify molecules responsible for blood pressure circadian rhythm formation under the control of the kidney biological clock in hypertension.

Methods

DNA microarray analysis was performed in kidneys from 5-week-old spontaneously hypertensive rats (SHRs)/Izm, stroke-prone SHR rats (SHRSP)/Izm, and Wistar Kyoto (WKY)/Izm rats. To detect variation, mouse tubular epithelial cells (TCMK-1) were stimulated with dexamethasone. We performed immunostaining and western blot analysis in the renal medulla of kidney fro

SUBMITTER: Murata Y 

PROVIDER: S-EPMC7814221 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature