Vaccine-related major cutaneous reaction size correlates with cellular-mediated immune responses after tularaemia immunisation.

ABSTRACT:

Objectives

Francisella tularensis, the causative agent of tularaemia, is an exceptionally infectious bacterium, potentially fatal for humans if left untreated and with the potential to be developed as a bioweapon. Both natural infection and live-attenuated vaccine strain (LVS) confer good protection against tularaemia. LVS vaccination is traditionally administered by scarification, and the formation of a cutaneous reaction or take at the vaccination site is recognised as a clinical correlate of protection. Although previous studies have suggested that high antibody titres following vaccination might serve as a useful surrogate marker, the immunological correlates of protection remain unknown.

Methods

We investigated the host T-cell-mediated immune (T-CMI) responses el

SUBMITTER: Salerno-Goncalves R 

PROVIDER: S-EPMC7814273 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature