Multiple origins of a frameshift insertion in a mitochondrial gene in birds and turtles.

ABSTRACT:

Background

During evolutionary history, molecular mechanisms have emerged to cope with deleterious mutations. Frameshift insertions in protein-coding sequences are extremely rare because they disrupt the reading frame. There are a few known examples of their correction through translational frameshifting, a process that enables ribosomes to skip nucleotides during translation to regain proper reading frame. Corrective frameshifting has been proposed to act on the single base pair insertion at position 174 of the mitochondrial NADH dehydrogenase subunit 3 gene (ND3) that has been observed in several turtles and birds. However, the relatively sparse taxonomic representation has hampered our understanding of the evolution of this insertion in vertebrates.

Results

Here, we analy

SUBMITTER: Andreu-Sanchez S 

PROVIDER: S-EPMC7814300 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature