Contrasting effects of adolescent and early-adult ethanol exposure on prelimbic cortical pyramidal neurons.

ABSTRACT:

Background

Adolescence and early-adulthood are vulnerable developmental periods during which binge drinking can have long-lasting effects on brain function. However, little is known about the effects of binge drinking on the pyramidal cells of the prelimbic cortex (PrL) during early and protracted withdrawal periods.

Methods

In the present study, we performed whole-cell patch clamp recordings and dendritic spine staining to examine the intrinsic excitability, spontaneous excitatory post-synaptic currents (sEPSCs), and spine morphology of pyramidal cells in the PrL from rats exposed to chronic intermittent ethanol (CIE) during adolescence or early-adulthood.

Results

Compared to chronic intermittent water (CIW)-treated controls, the excitability of PrL-L5 pyramidal neur

SUBMITTER: Galaj E 

PROVIDER: S-EPMC7814343 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature