Prevalence and Risk Factors for Mycobacterium tuberculosis Infection Among Adolescents in Rural South Africa.

ABSTRACT:

Background

We aimed to estimate the prevalence of and explore risk factors for Mycobacterium tuberculosis infection among adolescents in a high tuberculosis (TB) and human immunodeficiency virus (HIV) prevalence setting.

Methods

A cross-sectional study of adolescents (10-19 years) randomly selected from a demographic surveillance area (DSA) in rural KwaZulu-Natal, South Africa. We determined M tuberculosis infection status using the QuantiFERON-TB Gold-plus assay. We used HIV data from the DSA to estimate community-level adult HIV prevalence and random-effects logistic regression to identify risk factors for TB infection.

Results

We enrolled 1094 adolescents (548 [50.1%] female); M tuberculosis infection prevalence (weighted for nonresponse by age

SUBMITTER: Mzembe T 

PROVIDER: S-EPMC7814392 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature