Real World Use of Hypertonic Saline in Refractory Acute Decompensated Heart Failure: A U.S. Center's Experience.

ABSTRACT:

Objectives

The purpose of this study was to investigate real world safety and efficacy of hypertonic saline therapy in cases of refractory acute decompensated heart failure (ADHF) at a large U.S. academic medical center.

Background

Hypertonic saline therapy has been described as a potential management strategy for refractory ADHF, but experience in the United States is limited.

Methods

A retrospective analysis was performed in all patients receiving hypertonic saline for diuretic therapy-resistant ADHF at the authors' institution since March 2013. The primary analytic approach was a comparison of the trajectory of clinical variables prior to and after administration of hypertonic saline, with secondary focus on predictors of treatment response.

Results

A total

SUBMITTER: Griffin M 

PROVIDER: S-EPMC7814403 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature