Dysregulated follicular regulatory T cells and antibody responses exacerbate experimental autoimmune encephalomyelitis.

ABSTRACT:

Background

Follicular regulatory T (T_FR) cells are essential for the regulation of germinal center (GC) response and humoral self-tolerance. Dysregulated follicular helper T (T_FH) cell-GC-antibody (Ab) response secondary to dysfunctional T_FR cells is the root of an array of autoimmune disorders. The contribution of T_FR cells to the pathogenesis of multiple sclerosis (MS) and murine experimental autoimmune encephalomyelitis (EAE) remains largely unclear.

Methods

To determine the impact of dysregulated regulatory T cells (Tregs), T_FR cells, and Ab responses on EAE, we compared the MOG-induced EAE in mice with a FoxP3-specific ablation of the transcription factor Blimp1 to control mice. In vitro co-culture assays were used

SUBMITTER: Luo L 

PROVIDER: S-EPMC7814531 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature