Ultrastructural and molecular analysis of the origin and differentiation of cells mediating brittle star skeletal regeneration.

ABSTRACT:

Background

Regeneration is the ability to re-grow body parts or tissues after trauma, and it is widespread across metazoans. Cells involved in regeneration can arise from a pool of undifferentiated proliferative cells or be recruited from pre-existing differentiated tissues. Both mechanisms have been described in different phyla; however, the cellular and molecular mechanisms employed by different animals to restore lost tissues as well as the source of cells involved in regeneration remain largely unknown. Echinoderms are a clade of deuterostome invertebrates that show striking larval and adult regenerative abilities in all extant classes. Here, we use the brittle star Amphiura filiformis to investigate the origin and differentiation of cells involved in skeletal regeneration usin

SUBMITTER: Piovani L 

PROVIDER: S-EPMC7814545 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature