Identification of key biomarkers and immune infiltration in systemic lupus erythematosus by integrated bioinformatics analysis.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) is a multisystemic, chronic inflammatory disease characterized by destructive systemic organ involvement, which could cause the decreased functional capacity, increased morbidity and mortality. Previous studies show that SLE is characterized by autoimmune, inflammatory processes, and tissue destruction. Some seriously-ill patients could develop into lupus nephritis. However, the cause and underlying molecular events of SLE needs to be further resolved.

Methods

The expression profiles of GSE144390, GSE4588, GSE50772 and GSE81622 were downloaded from the Gene Expression Omnibus (GEO) database to obtain differentially expressed genes (DEGs) between SLE and healthy samples. The gene ontology (GO) and Kyoto Encyclopedia of Genes and G

SUBMITTER: Zhao X 

PROVIDER: S-EPMC7814551 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature