Characteristics and outcome of breast cancer-related microangiopathic haemolytic anaemia: a multicentre study.

ABSTRACT:

Background

Cancer-related microangiopathic haemolytic anaemia (MAHA) is a rare but life-threatening paraneoplastic syndrome. Only single cases or small series have been reported to date. We set up a retrospective multicentre study focusing on breast cancer-related MAHA.

Methods

Main inclusion criteria were known diagnosis of breast cancer, presence of schistocytes and either low haptoglobin or cytopenia and absence of any causes of MAHA other than breast cancer, including gemcitabine- or bevacizumab-based treatment. Patient characteristics, treatments and outcome were retrieved from digital medical records.

Results

Individual data from 54 patients with breast cancer-related MAHA were obtained from 7 centres. Twenty-three (44%) patients had a breast tumour with lobular

SUBMITTER: Alhenc-Gelas M 

PROVIDER: S-EPMC7814553 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature