Inhibition of TGFβ improves hematopoietic stem cell niche and ameliorates cancer-related anemia.

ABSTRACT:

Background

Cancer cachexia is a wasting syndrome that is quite common in terminal-stage cancer patients. Cancer-related anemia is one of the main features of cancer cachexia and mostly results in a poor prognosis. The disadvantages of the current therapies are obvious, but few new treatments have been developed because the pathological mechanism remains unclear.

Methods

C57BL/6 mice were subcutaneously injected with Lewis lung carcinoma cells to generate a cancer-related anemia model. The treated group received daily intraperitoneal injections of SB505124. Blood parameters were determined with a routine blood counting analyzer. Erythroid cells and hematopoietic stem/progenitor cells were analyzed by flow cytometry. The microarchitecture changes of the femurs were determined

SUBMITTER: Wang B 

PROVIDER: S-EPMC7814632 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature