Production of biologically active human interleukin-10 by Bifidobacterium bifidum BGN4.

ABSTRACT:

Background

Bifidobacterium spp. are representative probiotics that play an important role in the health of their hosts. Among various Bifidobacterium spp., B. bifidum BGN4 exhibits relatively high cell adhesion to colonic cells and has been reported to have various in vivo and in vitro bio functionalities (e.g., anti-allergic effect, anti-cancer effect, and modulatory effects on immune cells). Interleukin-10 (IL-10) has emerged as a major suppressor of immune response in macrophages and other antigen presenting cells and plays an essential role in the regulation and resolution of inflammation. In this study, recombinant B. bifidum BGN4 [pBESIL10] was developed to deliver human IL-10 effectively to the intestines.

Results

The vector pBESIL10 was constructed by cloning the hum

SUBMITTER: Hong N 

PROVIDER: S-EPMC7814708 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature