Reference Ability Neural Network-selective functional connectivity across the lifespan.

ABSTRACT: Previous studies have demonstrated that four latent variables, or reference abilities (RAs), can account for the majority of age-related changes in cognition: these being episodic memory, fluid reasoning, speed of processing, and vocabulary. In the current study, we focused on RA-selective functional connectivity patterns that vary with both age and behavior. We analyzed fMRI data from 287 community-dwelling adults (20-80 years) on a battery of tests relating to the four RAs (three tests per RA = 12 tests). Functional connectivity values were calculated between a pre-defined set of 264 ROIs (nodes). Across all participants, we (a) identified connections (edges) that correlated with an RA-specific indicator variable and, indexing only these edges; (b) performed linear regression analysis pe

SUBMITTER: Argiris G 

PROVIDER: S-EPMC7814764 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature