Estimating Local Cellular Density in Glioma Using MR Imaging Data.

ABSTRACT:

Background and purpose

Increased cellular density is a hallmark of gliomas, both in the bulk of the tumor and in areas of tumor infiltration into surrounding brain. Altered cellular density causes altered imaging findings, but the degree to which cellular density can be quantitatively estimated from imaging is unknown. The purpose of this study was to discover the best MR imaging and processing techniques to make quantitative and spatially specific estimates of cellular density.

Materials and methods

We collected stereotactic biopsies in a prospective imaging clinical trial targeting untreated patients with gliomas at our institution undergoing their first resection. The data included preoperative MR imaging with conventional anatomic, diffusion, perfusion, and permeability

SUBMITTER: Gates EDH 

PROVIDER: S-EPMC7814791 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature