Co-occurring defect analysis: A platform for analyzing birth defect co-occurrence in registries.

ABSTRACT:

Background

Few studies have systematically evaluated birth defect co-occurrence patterns, perhaps, in part, due to the lack of software designed to implement large-scale, complex analytic methods.

Methods

We created an R-based platform, "co-occurring defect analysis" (CODA), designed to implement analyses of birth defect co-occurrence patterns in birth defect registries. CODA uses an established algorithm for calculating the observed-to-expected ratio of a given birth defect combination, accounting for the known tendency of birth defects to co-occur nonspecifically. To demonstrate CODA's feasibility, we evaluated the computational time needed to assess 2- to 5-way combinations of major birth defects in the Texas Birth Defects Registry (TBDR) (1999-2014). We report on two exa

SUBMITTER: Benjamin RH 

PROVIDER: S-EPMC7814855 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature