Dataset Information

Radiosynthesis, in vitro and preliminary in vivo evaluation of the novel glutamine derived PET tracers [¹⁸F]fluorophenylglutamine and [¹⁸F]fluorobiphenylglutamine.

ABSTRACT:

Introduction

Glucose has been deemed the driving force of tumor growth for decades. However, research has shown that several tumors metabolically shift towards glutaminolysis. The development of radiolabeled glutamine derivatives could be a useful molecular imaging tool for visualizing these tumors. We elaborated on the glutamine-derived PET tracers by developing two novel probes, namely [¹⁸F]fluorophenylglutamine and [¹⁸F]fluorobiphenylglutamine.

Materials and methods

Both tracers were labelled with fluorine-18 using our recently reported ruthenium-based direct aromatic fluorination method. Their affinity was evaluated with a [³H]glutamine inhibition experiment in a human PC-3 and a rat F98 cell line. The imaging potential of [¹⁸F

SUBMITTER: Baguet T

PROVIDER: S-EPMC7814958 | biostudies-literature | 2020 Jul - Aug

REPOSITORIES: biostudies-literature

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Dataset Information

Radiosynthesis, in vitro and preliminary in vivo evaluation of the novel glutamine derived PET tracers [¹⁸F]fluorophenylglutamine and [¹⁸F]fluorobiphenylglutamine.

Introduction

Materials and methods

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Radiosynthesis, in vitro and preliminary in vivo evaluation of the novel glutamine derived PET tracers [18F]fluorophenylglutamine and [18F]fluorobiphenylglutamine.

Introduction

Materials and methods

OmicsDI is part of the ELIXIR infrastructure

Tweets

Radiosynthesis, in vitro and preliminary in vivo evaluation of the novel glutamine derived PET tracers [¹⁸F]fluorophenylglutamine and [¹⁸F]fluorobiphenylglutamine.