Synthesis, Characterization, and Application of a Highly Hydrophilic Triarylmethyl Radical for Biomedical EPR.

ABSTRACT: Stable tetrathiatriarylmethyl radicals have significantly contributed to the recent progress in biomedical electron paramagnetic resonance (EPR) due to their unmatched stability in biological media and long relaxation times. However, the lipophilic core of the most commonly used structure (Finland trityl) is responsible for its interaction with plasma biomacromolecules, such as albumin, and self-aggregation at high concentrations and/or low pH. While Finland trityl is generally considered inert toward many reactive radical species, we report that sulfite anion radical efficiently substitutes the three carboxyl moieties of Finland trityl with a high rate constant of 3.53 × 10⁸ M^-1 s^-1, leading to a trisulfonated Finland trityl radical. This newly synthesized

SUBMITTER: Sanzhaeva U 

PROVIDER: S-EPMC7814971 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature