CKMT1B is a potential prognostic biomarker and associated with immune infiltration in Lower-grade glioma.

ABSTRACT:

Background

Lower-grade glioma (LGG) is the most common histology identified in glioma. CKMT1B has not been investigated in glioma. The purpose of this research was to investigate the prognostic value of CKMT1B and its correlation with immune infiltration in LGG.

Methods

We used Gene Expression Profiling Interactive Analysis (GEPIA) to analyze the expression of CKMT1B in LGG. Univariate and multivariate Cox regression analyses were used to assess the effect of CKMT1B expression and screened variables on survival. The correlation between CKMT1B and immune infiltration was evaluated by TIMER and CIBERSORT. Moreover, the possible biological functions of CKMT1B were studied by GSEA. The statistical analysis was conducted by R software.

Results

The expression of CKMT1B was

SUBMITTER: Shi H 

PROVIDER: S-EPMC7815138 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature