Enhanced biofilm and extracellular matrix production by chronic carriage versus acute isolates of Salmonella Typhi.

ABSTRACT: Salmonella Typhi is the primary causative agent of typhoid fever; an acute systemic infection that leads to chronic carriage in 3-5% of individuals. Chronic carriers are asymptomatic, difficult to treat and serve as reservoirs for typhoid outbreaks. Understanding the factors that contribute to chronic carriage is key to development of novel therapies to effectively resolve typhoid fever. Herein, although we observed no distinct clustering of chronic carriage isolates via phylogenetic analysis, we demonstrated that chronic isolates were phenotypically distinct from acute infection isolates. Chronic carriage isolates formed significantly thicker biofilms with greater biomass that correlated with significantly higher relative levels of extracellular DNA (eDNA) and DNABII proteins than biofilm

SUBMITTER: Devaraj A 

PROVIDER: S-EPMC7815147 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature