Common Regulatory Targets of NFIA, NFIX and NFIB during Postnatal Cerebellar Development.

ABSTRACT: Transcriptional regulation plays a central role in controlling neural stem and progenitor cell proliferation and differentiation during neurogenesis. For instance, transcription factors from the nuclear factor I (NFI) family have been shown to co-ordinate neural stem and progenitor cell differentiation within multiple regions of the embryonic nervous system, including the neocortex, hippocampus, spinal cord and cerebellum. Knockout of individual Nfi genes culminates in similar phenotypes, suggestive of common target genes for these transcription factors. However, whether or not the NFI family regulates common suites of genes remains poorly defined. Here, we use granule neuron precursors (GNPs) of the postnatal murine cerebellum as a model system to analyse regulatory targets of three membe

SUBMITTER: Fraser J 

PROVIDER: S-EPMC7815246 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature