Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations.

ABSTRACT: Laboratory experimental evolution provides a window into the details of the evolutionary process. To investigate the consequences of long-term adaptation, we evolved 205 Saccharomyces cerevisiae populations (124 haploid and 81 diploid) for ~10,000,000 generations in three environments. We measured the dynamics of fitness changes over time, finding repeatable patterns of declining adaptability. Sequencing revealed that this phenotypic adaptation is coupled with a steady accumulation of mutations, widespread genetic parallelism, and historical contingency. In contrast to long-term evolution in E. coli, we do not observe long-term coexistence or populations with highly elevated mutation rates. We find that evolution in diploid populations involves both fixation of heterozygous m

SUBMITTER: Johnson MS 

PROVIDER: S-EPMC7815316 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature