Resistance to anaplastic lymphoma kinase inhibitors: knowing the enemy is half the battle won.

ABSTRACT: Anaplastic lymphoma kinase (ALK) translocations are responsible of neoplastic transformation in a limited subset of non-small cell lung cancer (NSCLC) patients. In recent years outcomes of these patients improved due to the development and clinical availability of specific and extremely active targeted therapies [i.e., next-generation Tyrosine Kinase Inhibitors (TKI)]: ALK+ patients are now reaching impressive results when treated with more potent inhibitors upfront with an average median progression-free survival (mPFS) around 35 months. However, under drug pressure, cancer cells develop resistance and patients eventually progress. Multiple mechanisms of intrinsic or acquired resistance have been extensively characterized. Less potent ALK inhibitors (ALKi)-like crizotinib-usually t

SUBMITTER: Tabbo F 

PROVIDER: S-EPMC7815358 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature