The protective effects of granulocyte-macrophage colony-stimulating factor against radiation-induced lung injury.

ABSTRACT:

Background

Radiation-induced lung injury (RILI) is a common complication of thoracic cancer radiation therapy. Currently, there is no effective treatment for RILI. RILI is associated with chronic inflammation, this injury is perpetuated by the stimulation of chemokines and proinflammatory cytokines. Recent studies have demonstrated that granulocyte-macrophage colony-stimulating factor (GM-CSF) plays a pivotal role in inflammation and fibrosis. This study aimed to investigate the protective effect of GM-CSF against the development of RILI in lung tissue.

Method

First, a single fraction of radiation at a dose of 16 Gy was targeted at the entire thorax of wild-type (WT) C57BL/6 mice and GM-CSF^-/- mice to induce RILI. Second, we detected the radioprotective effects of

SUBMITTER: Hu D 

PROVIDER: S-EPMC7815363 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature