Familial Risks between Pernicious Anemia and Other Autoimmune Diseases in the Population of Sweden.

ABSTRACT:

Background

Pernicious anemia (PA) is an autoimmune disease (AID) which is caused by lack of vitamin B12 (cobalamin) due to its impaired uptake. PA is a multifactorial disease which is associated with a number of other AID comorbidities and which is manifested as part of autoimmune polyglandular syndrome. Due to the shortage of family studies on PA, we planned to address the problem by assessing familial risks for concordant PA between family members and for discordant PA in families of other AID patients.

Methods

We collected data on patients diagnosed with AIDs from the Swedish hospitals and family data from a population register. We calculated standardized incidence ratios (SIRs) in families for concordant and discordant risks.

Results

The number of PA patients in t

SUBMITTER: Li X 

PROVIDER: S-EPMC7815416 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature