An atlas on risk factors for multiple sclerosis: a Mendelian randomization study.

ABSTRACT:

Objectives

We conducted a systematic review and wide-angled Mendelian randomization (MR) study to examine the association between possible risk factors and multiple sclerosis (MS).

Methods

We used MR analysis to assess the associations between 65 possible risk factors and MS using data from a genome-wide association study including 14 498 cases and 24 091 controls of European ancestry. For 18 exposures not suitable for MR analysis, we conducted a systematic review to obtain the latest meta-analyses evidence on their associations with MS.

Results

Childhood and adulthood body mass index were positively associated with MS, whereas physical activity and serum 25-hydroxyvitamin D were inversely associated with MS. There was evidence of possible associations of type 2 diabe

SUBMITTER: Yuan S 

PROVIDER: S-EPMC7815542 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature