Cortical diffusivity investigation in posterior cortical atrophy and typical Alzheimer's disease.

ABSTRACT:

Objectives

To investigate the global cortical and regional quantitative features of cortical neural architecture in the brains of patients with posterior cortical atrophy (PCA) and typical Alzheimer's disease (tAD) compared with elderly healthy controls (HC).

Methods

A novel diffusion MRI method, that has been shown to correlate with minicolumnar organization changes in the cerebral cortex, was used as a surrogate of neuropathological changes in dementia. A cohort of 15 PCA patients, 23 tAD and 22 healthy elderly controls (HC) were enrolled to investigate the changes in cortical diffusivity among groups. For each subject, 3 T MRI T1-weighted images and diffusion tensor imaging (DTI) scans were analysed to extract novel cortical DTI derived measures (AngleR, PerpPD and ParlPD

SUBMITTER: Torso M 

PROVIDER: S-EPMC7815619 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature