Impaired naming performance in temporal lobe epilepsy: language fMRI responses are modulated by disease characteristics.

ABSTRACT:

Objective

To investigate alterations of language networks and their relation to impaired naming performance in temporal lobe epilepsy (TLE) using functional MRI.

Methods

Seventy-two adult TLE patients (41 left) and 36 controls were studied with overt auditory and picture naming fMRI tasks to assess temporal lobe language areas, and a covert verbal fluency task to probe frontal lobe language regions. Correlation of fMRI activation with clinical naming scores, and alteration of language network patterns in relation to epilepsy duration, age at onset and seizure frequency, were investigated with whole-brain multiple regression analyses.

Results

Auditory and picture naming fMRI activated the left posterior temporal lobe, and stronger activation correlated with better clin

SUBMITTER: Trimmel K 

PROVIDER: S-EPMC7815622 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature