Progressive interstitial lung disease in patients with systemic sclerosis-associated interstitial lung disease in the EUSTAR database.

ABSTRACT:

Objectives

To identify overall disease course, progression patterns and risk factors predictive for progressive interstitial lung disease (ILD) in patients with systemic sclerosis-associated ILD (SSc-ILD), using data from the European Scleroderma Trials And Research (EUSTAR) database over long-term follow-up.

Methods

Eligible patients with SSc-ILD were registered in the EUSTAR database and had measurements of forced vital capacity (FVC) at baseline and after 12±3 months. Long-term progressive ILD and progression patterns were assessed in patients with multiple FVC measurements. Potential predictors of ILD progression were analysed using multivariable mixed-effect models.

Results

826 patients with SSc-ILD were included. Over 12±3 months, 219 (27%) showed progressive IL

SUBMITTER: Hoffmann-Vold AM 

PROVIDER: S-EPMC7815627 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature