Mutational sensitivity of D614G in spike protein of SARS-CoV-2 in Jordan.

ABSTRACT:

Background

Spike protein is the surface glycoprotein of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) necessary for the entry of the virus via the transmembrane receptors of the human respiratory cells causing COVID-19 disease.

Aim

Here, we aimed to predict the three-dimensional monomer structure of spike protein of SARS-CoV-2 from 20 Jordanian nasopharyngeal samples and to determine the percentage of single amino acid variants (SAV) in the spike protein of SARS-CoV-2.

Methods

The output of the Protein Homology/analogY Recognition Engine V 2.0 (Phyre2) found four single amino acid variants in the spike gene.

Results

The first variant represented by 5% of samples that showed tyrosine deletion at Y144 located in the N terminal domain. The secon

SUBMITTER: Al-Zyoud W 

PROVIDER: S-EPMC7815659 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature