Electronic cigarette aerosols alter the expression of cisplatin transporters and increase drug resistance in oral cancer cells.

ABSTRACT: Tobacco smoking is the leading preventable cause of cancer. Moreover, continued smoking during cancer therapy reduces overall survival. Aware of the negative consequences of tobacco smoking and the challenges of smoking cessation, cancer patients are inquiring whether they should switch to electronic cigarettes (e-cigarettes). To obtain evidence-based data to inform this decision, we examined the effects of e-cigarette aerosol exposure on cisplatin resistance in head and neck cancer cells. Our results show that cancer cells exposed to e-cigarette aerosol extracts and treated with cisplatin have a significant decrease in cell death, increase in viability, and increase in clonogenic survival when compared to non-exposed cells. Moreover, exposure to e-cigarette aerosol extracts increased the

SUBMITTER: Manyanga J 

PROVIDER: S-EPMC7815770 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature