Dynamic functional connectivity as a neural correlate of fatigue in multiple sclerosis.

ABSTRACT:

Background

More than 80% of multiple sclerosis (MS) patients experience symptoms of fatigue. MS-related fatigue is only partly explained by structural (lesions and atrophy) and functional (brain activation and conventional static functional connectivity) brain properties.

Objectives

To investigate the relationship of dynamic functional connectivity (dFC) with fatigue in MS patients and to compare dFC with commonly used clinical and MRI parameters.

Methods

In 35 relapsing-remitting MS patients (age: 42.83 years, female/male: 20/15, disease duration: 11 years) and 19 healthy controls (HCs) (age: 41.38 years, female/male: 11/8), fatigue was measured using the CIS-20r questionnaire at baseline and at 6-month follow-up. All subjects underwent structural and resting-state f

SUBMITTER: Tijhuis FB 

PROVIDER: S-EPMC7815811 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature