Cortical Tracking of the Speech Envelope in Logopenic Variant Primary Progressive Aphasia.

ABSTRACT: Logopenic variant primary progressive aphasia (lvPPA) is a neurodegenerative language disorder primarily characterized by impaired phonological processing. Sentence repetition and comprehension deficits are observed in lvPPA and linked to impaired phonological working memory, but recent evidence also implicates impaired speech perception. Currently, neural encoding of the speech envelope, which forms the scaffolding for perception, is not clearly understood in lvPPA. We leveraged recent analytical advances in electrophysiology to examine speech envelope encoding in lvPPA. We assessed cortical tracking of the speech envelope and in-task comprehension of two spoken narratives in individuals with lvPPA (n = 10) and age-matched (n = 10) controls. Despite markedly reduced narrativ

SUBMITTER: Dial HR 

PROVIDER: S-EPMC7815818 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature