Improved image reconstruction of ⁸⁹Zr-immunoPET studies using a Bayesian penalized likelihood reconstruction algorithm.

ABSTRACT:

Purpose

The aim of this study was to evaluate the use of a Bayesian penalized likelihood reconstruction algorithm (Q.Clear) for ⁸⁹Zr-immunoPET image reconstruction and its potential to improve image quality and reduce the administered activity of ⁸⁹Zr-immunoPET tracers.

Methods

Eight ⁸⁹Zr-immunoPET whole-body PET/CT scans from three ⁸⁹Zr-immunoPET clinical trials were selected for analysis. On average, patients were imaged 6.3 days (range 5.0-8.0 days) after administration of 69 MBq (range 65-76 MBq) of [⁸⁹Zr]Zr-DFO-daratumumab, [⁸⁹Zr]Zr-DFO-pertuzumab, or [⁸⁹Zr]Zr-DFO-trastuzumab. List-mode PET data was retrospectively reconstructed using Q.Clear with incremental β-values from 150 to 7200, as well

SUBMITTER: Kirchner J 

PROVIDER: S-EPMC7815860 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature