Photoperiodic regulation of dopamine signaling regulates seasonal changes in retinal photosensitivity in mice.

ABSTRACT: At high latitudes, approximately 10% of people suffer from depression during the winter season, a phenomenon known as seasonal affective disorder (SAD). Shortened photoperiod and/or light intensity during winter season are risk factors for SAD, and bright light therapy is an effective treatment. Interestingly, reduced retinal photosensitivity along with the mood is observed in SAD patients in winter. However, the molecular basis underlying seasonal changes in retinal photosensitivity remains unclear, and pharmacological intervention is required. Here we show photoperiodic regulation of dopamine signaling and improvement of short day-attenuated photosensitivity by its pharmacological intervention in mice. Electroretinograms revealed dynamic seasonal changes in retinal photosensitivity. Tran

SUBMITTER: Okimura K 

PROVIDER: S-EPMC7815869 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature