Mass eradication of Helicobacter pylori to reduce gastric cancer incidence and mortality: a long-term cohort study on Matsu Islands.

ABSTRACT:

Objective

Although mass eradication of Helicobacter pylori has been proposed as a means to eliminate gastric cancer, its long-term effects remain unclear.

Design

Mass eradication of H. pylori infection was launched in 2004 and continued until 2018 for a high-risk Taiwanese population aged 30 years or older dwelling on Matsu Islands with prevalent H. pylori infection. Test positives for the ¹³C-urea breath test underwent eradication therapy. We evaluated the effectiveness of the mass eradication in reducing two main outcomes, incidence and mortality rates of gastric cancer, until the end of 2016 and 2018, respectively.

Results

After six rounds of mass screening and eradication, the coverage rate reached 85.5% (6512/7616). The referral ra

SUBMITTER: Chiang TH 

PROVIDER: S-EPMC7815911 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature