Clinical feasibility of longitudinal lateral ventricular volume measurements on T2-FLAIR across MRI scanner changes.

ABSTRACT:

Background

Greater brain atrophy is associated with disability progression (DP) in patients with multiple sclerosis (PwMS). However, methodological challenges limit its routine clinical use.

Objective

To determine the feasibility of atrophy measures as markers of DP in PwMS scanned across different MRI field strengths.

Methods

A total of 980 PwMS were scanned on either 1.5 T or 3.0 T MRI scanners. Demographic and clinical data were retrospectively collected, and the presence of DP was determined according to standard clinical trial criteria. Lateral ventricular volume (LVV) change was measured with the NeuroSTREAM technique on clinical routine T2-FLAIR images. Percent brain volume change (PBVC) was measured using SIENA and ventricular cerebrospinal fluid (vCSF) % chan

SUBMITTER: Jakimovski D 

PROVIDER: S-EPMC7816007 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature