Accessible chromatin regions and their functional interrelations with gene transcription and epigenetic modifications in sorghum genome.

ABSTRACT: Accessible chromatin regions (ACRs) provide physical scaffolds to recruit transcriptional co-regulators and displace their nearby nucleosomes in multiple plant species. Characterization of ACRs and investigation of their biological effects in Sorghum bicolor has lagged behind. Regulation of gene expression relies on the transcriptional co-regulators that are recruited to ACRs to affect epigenomic modifications of surrounding nucleosomes. In this study, we employed transposase-accessible chromatin sequencing to identify ACRs and decipher how the presence of ACRs affects gene expression and epigenetic signatures in the Sorghum genome. As a result, 21 077 ACRs, which are mapped to 22.9% of genes and 2.7% of repeats, were identified. The profiling of ACRs on gene structures revea

SUBMITTER: Zhou C 

PROVIDER: S-EPMC7816095 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature