Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study.

ABSTRACT:

Importance

Smoking is associated with atherosclerotic cardiovascular disease, but the relative contribution to each subtype (coronary artery disease [CAD], peripheral artery disease [PAD], and large-artery stroke) remains less well understood.

Objective

To determine the association between genetic liability to smoking and risk of CAD, PAD, and large-artery stroke.

Design, setting, and participants

Mendelian randomization study using summary statistics from genome-wide associations of smoking (UK Biobank; up to 462 690 individuals), CAD (Coronary Artery Disease Genome Wide Replication and Meta-analysis plus the Coronary Artery Disease Genetics Consortium; up to 60 801 cases, 123 504 controls), PAD (VA Million Veteran Program; up to 24 009 cases, 150 983 controls), and

SUBMITTER: Levin MG 

PROVIDER: S-EPMC7816104 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature