Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets.

ABSTRACT: Tissue-resident memory T (T_RM) cells provide key adaptive immune responses in infection, cancer, and autoimmunity. However, transcriptional heterogeneity of human intestinal T_RM cells remains undefined. Here, we investigate transcriptional and functional heterogeneity of human T_RM cells through study of donor-derived T_RM cells from intestinal transplant recipients. Single-cell transcriptional profiling identifies two transcriptional states of CD8⁺ T_RM cells, delineated by ITGAE and ITGB2 expression. We define a transcriptional signature discriminating these populations, including differential expression of cytotoxicity- and residency-associated genes. Flow cytometry of recipient-derived cells infiltrating the graft, and lymp

SUBMITTER: FitzPatrick MEB 

PROVIDER: S-EPMC7816164 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature