Activation of dopaminergic VTA inputs to the mPFC ameliorates chronic stress-induced breast tumor progression.

ABSTRACT:

Aims

Chronic stress plays an important role in promoting the progression and migration of cancers. However, little is known of any direct impact on tumor progression related to the regulation of emotion-related circuitry. The aim of this study was to explore the neural-circuit mechanisms underlying stress-induced progression of cancers and the impact of emotion-related regulation of circuitry on tumor growth.

Methods

Optogenetic manipulation was applied to unpredictable chronic mild stress (UCMS)-treated mice bearing breast tumor cell. The stress-related hormones, tumor-related cytokines, the tyrosine hydroxylase (TH)-positive neurons and their fibers, dopamine receptor-positive cells, and anxiety level were measured using ELISA, immunohistochemical staining, fluorescence in

SUBMITTER: Xu XR 

PROVIDER: S-EPMC7816210 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature