Voxel-wise partial volume correction method for accurate estimation of tissue sodium concentration in ²³ Na-MRI at 7 T.

ABSTRACT: Sodium is crucial for the maintenance of cell physiology, and its regulation of the sodium-potassium pump has implications for various neurological conditions. The distribution of sodium concentrations in tissue can be quantitatively evaluated by means of sodium MRI (²³ Na-MRI). Despite its usefulness in diagnosing particular disease conditions, tissue sodium concentration (TSC) estimated from ²³ Na-MRI can be strongly biased by partial volume effects (PVEs) that are induced by broad point spread functions (PSFs) as well as tissue fraction effects. In this work, we aimed to propose a robust voxel-wise partial volume correction (PVC) method for ²³ Na-MRI. The method is based on a linear regression (LR) approach to correct for tissue fraction effects, but it

SUBMITTER: Kim SY 

PROVIDER: S-EPMC7816248 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature