Bardet-Biedl syndrome: Weight patterns and genetics in a rare obesity syndrome.

ABSTRACT:

Background

Bardet-Biedl syndrome (BBS) is a rare genetic disorder that severely inhibits primary cilia function. BBS is typified by obesity in adulthood, but pediatric weight patterns, and thus optimal periods of intervention, are poorly understood.

Objectives

To examine body mass differences by age, gender, and genotype in children and adolescents with BBS.

Methods

We utilized the largest international registry of BBS phenotypes. Anthropometric and genetic data were obtained from medical records or participant/family interviews. Participants were stratified by age and sex categories. Genotype and obesity phenotype were investigated in a subset of participants with available data.

Results

Height and weight measurements were available for 552 unique individuals

SUBMITTER: Pomeroy J 

PROVIDER: S-EPMC7816264 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature