Effects of in IL-1B/IL-1RN variants on the susceptibility to head and neck cancer in a chinese Han population.

ABSTRACT:

Background

The study aimed to evaluate the relationship of IL-1B/IL-1RN polymorphisms to the predisposition of head and neck cancer (HNC) in a Chinese Han population.

Methods

Nine single-nucleotide polymorphisms (SNPs) in IL-1B/IL-1RN were genotyped based on Agena MassARRAY platform. Logistic regression models were used to analyze the genetic association between these SNPs and HNC risk by calculating odds ratios (ORs) and 95% confidence intervals (CI). Haplotype analysis were performed using Haploview program and logistic regression model.

Results

The genetic association between rs1143643 in IL-1B and the higher risk of HNC was found (OR = 1.23, 95% CI 1.04-1.46) in the overall. IL-1RN rs17042888 was related to a reduced risk of HNC in the subjects aged > 46 years (OR

SUBMITTER: Yin Y 

PROVIDER: S-EPMC7816368 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature